19 мар. 2024 г. ... SUMMARY AND RECOMMENDATIONS · INTRODUCTION · MECHANISM OF ACTION · RESISTANCE · SPECTRUM OF ACTIVITY · PHARMACODYNAMICS AND PHARMACOKINETICS · DOSAGE ...
www.uptodate.comMechanism of action ... Trimethoprim inhibits dihydrofolate reductase, the enzyme that catalyzes the last step of bacterial folic acid synthesis (see Fig. 4-7).
www.sciencedirect.comBACTRIM™ sulfamethoxazole and trimethoprim DS. (double strength) tablets and tablets USP. To reduce the development of drug-resistant bacteria and maintain ...
www.accessdata.fda.govMechanism of Action: ... Sulfamethoxazole inhibits the synthesis of dihydrofolic acid. Trimethoprim inhibits thymidine and DNA synthesis. These two agents act ...
antimicrobe.orgTrimethoprim exerts antimicrobial activity by blocking the reduction of dihydrofolate to tetrahydrofolate, the active form of folic acid, by susceptible ...
pubmed.ncbi.nlm.nih.govTrimethoprim exerts antimicrobial activity by blocking the reduction of dihydrofolate to tetrahydrofolate, the active form of folic acid, by susceptible ...
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Sulfamethoxazole competitively inhibits dihydropteroate synthase, the enzyme responsible for bacterial conversion of PABA to dihydrofolic acid. Inhibition of ...
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This sequential blockade of 2 enzymes in one pathway results in an effective bactericidal action. The drug was introduced in the late 1960s based on several ...
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Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of ...
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Mechanism of Action ... Sulfamethoxazole is hepatically metabolized by the CYP450 system; it is a CYP2C9 inhibitor. Its half-life is 6 to 12 hours, increasing to ...
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